The neural implementation of operant conditioning with few trials is unclear. We propose a Hippocampus-Inspired Cognitive Architecture (HICA) as a neural mechanism for operant conditioning. HICA explains a learning mechanism in which agents can learn a new behavior policy in a few trials, as mammals do in operant conditioning experiments. HICA is composed of two different types of modules. One is a universal learning module type that represents a cortical column in the neocortex gray matter. The working principle is modeled as Modulated Heterarchical Prediction Memory (mHPM). In mHPM, each module learns to predict a succeeding input vector given the sequence of the input vectors from lower layers and the context vectors from higher layers. The prediction is fed into the lower layers as a context signal (top-down feedback signaling), and into the higher layers as an input signal (bottom-up feedforward signaling). Rewards modulate the learning rate in those modules to memorize meaningful sequences effectively. In mHPM, each module updates in a local and distributed way compared to conventional end-to-end learning with backpropagation of the single objective loss. This local structure enables the heterarchical network of modules. The second type is an innate, special-purpose module representing various organs of the brain's subcortical system. Modules modeling organs such as the amygdala, hippocampus, and reward center are pre-programmed to enable instinctive behaviors. The hippocampus plays the role of the simulator. It is an autoregressive prediction model of the top-most level signal with a loop structure of memory, while cortical columns are lower layers that provide detailed information to the simulation. The simulation becomes the basis for learning with few trials and the deliberate planning required for operant conditioning.

人工智能革命（AI）提出了巨大的存储和数据处理要求。大量的功耗和硬件开销已成为构建下一代AI硬件的主要挑战。为了减轻这种情况，神经形态计算引起了极大的关注，因为它在功耗非常低的功能方面具有出色的数据处理能力。尽管无情的研究已经进行了多年，以最大程度地减少神经形态硬件的功耗，但我们离达到人脑的能源效率还有很长的路要走。此外，设计复杂性和过程变化阻碍了当前神经形态平台的大规模实现。最近，由于其出色的速度和功率指标，在低温温度中实施神经形态计算系统的概念引起了人们的兴趣。可以设计几种低温装置，可作为具有超低功率需求的神经形态原始设备。在这里，我们全面回顾了低温神经形态硬件。我们将现有的低温神经形态硬件分类为几个分层类别，并根据关键性能指标绘制比较分析。我们的分析简洁地描述了相关电路拓扑的操作，并概述了最先进的技术平台遇到的优势和挑战。最后，我们提供了见解，以规避这些挑战，以实现未来的研究发展。

条件密度估计（CDE）是估算某些输入上的事件概率的任务。神经网络（NN）还可用于计算连续域的输出分布，这可以被视为回归任务的扩展。然而，在不知道其一般形式的信息的情况下，难以明确地近似分布。为了符合任意条件分布，将连续域分离成箱是一种有效的策略，只要我们拥有足够窄的箱和非常大的数据。然而，收集足够的数据通常很难到达，并且在许多情况下，特别是在多变量Cde的诅咒中的诅咒中的那种理想。在本文中，我们展示了使用基于Deconvolution的神经网络框架建模自由形式条件分布的好处，在离散化中应对数据缺陷问题。它具有灵活性的优点，但也利用了解压缩层提供的分层平滑度。我们将我们的方法与许多其他密度估计方法进行比较，并表明我们的解卷积密度网络（DDN）优于许多单变量和多变量任务的竞争方法。 DDN的代码可在https://github.com/nbiclab/ddn上获得。

Despite recent advances of AI research in many application-specific domains, we do not know how to build a human-level artificial intelligence (HLAI). We conjecture that learning from others' experience with the language is the essential characteristic that distinguishes human intelligence from the rest. Humans can update the action-value function with the verbal description as if they experience states, actions, and corresponding rewards sequences firsthand. In this paper, we present a classification of intelligence according to how individual agents learn and propose a definition and a test for HLAI. The main idea is that language acquisition without explicit rewards can be a sufficient test for HLAI.

The ability to distinguish between different movie scenes is critical for understanding the storyline of a movie. However, accurately detecting movie scenes is often challenging as it requires the ability to reason over very long movie segments. This is in contrast to most existing video recognition models, which are typically designed for short-range video analysis. This work proposes a State-Space Transformer model that can efficiently capture dependencies in long movie videos for accurate movie scene detection. Our model, dubbed TranS4mer, is built using a novel S4A building block, which combines the strengths of structured state-space sequence (S4) and self-attention (A) layers. Given a sequence of frames divided into movie shots (uninterrupted periods where the camera position does not change), the S4A block first applies self-attention to capture short-range intra-shot dependencies. Afterward, the state-space operation in the S4A block is used to aggregate long-range inter-shot cues. The final TranS4mer model, which can be trained end-to-end, is obtained by stacking the S4A blocks one after the other multiple times. Our proposed TranS4mer outperforms all prior methods in three movie scene detection datasets, including MovieNet, BBC, and OVSD, while also being $2\times$ faster and requiring $3\times$ less GPU memory than standard Transformer models. We will release our code and models.

Learning policies from fixed offline datasets is a key challenge to scale up reinforcement learning (RL) algorithms towards practical applications. This is often because off-policy RL algorithms suffer from distributional shift, due to mismatch between dataset and the target policy, leading to high variance and over-estimation of value functions. In this work, we propose variance regularization for offline RL algorithms, using stationary distribution corrections. We show that by using Fenchel duality, we can avoid double sampling issues for computing the gradient of the variance regularizer. The proposed algorithm for offline variance regularization (OVAR) can be used to augment any existing offline policy optimization algorithms. We show that the regularizer leads to a lower bound to the offline policy optimization objective, which can help avoid over-estimation errors, and explains the benefits of our approach across a range of continuous control domains when compared to existing state-of-the-art algorithms.

Several self-supervised representation learning methods have been proposed for reinforcement learning (RL) with rich observations. For real-world applications of RL, recovering underlying latent states is crucial, particularly when sensory inputs contain irrelevant and exogenous information. In this work, we study how information bottlenecks can be used to construct latent states efficiently in the presence of task-irrelevant information. We propose architectures that utilize variational and discrete information bottlenecks, coined as RepDIB, to learn structured factorized representations. Exploiting the expressiveness bought by factorized representations, we introduce a simple, yet effective, bottleneck that can be integrated with any existing self-supervised objective for RL. We demonstrate this across several online and offline RL benchmarks, along with a real robot arm task, where we find that compressed representations with RepDIB can lead to strong performance improvements, as the learned bottlenecks help predict only the relevant state while ignoring irrelevant information.

Artificial intelligence(AI) systems based on deep neural networks (DNNs) and machine learning (ML) algorithms are increasingly used to solve critical problems in bioinformatics, biomedical informatics, and precision medicine. However, complex DNN or ML models that are unavoidably opaque and perceived as black-box methods, may not be able to explain why and how they make certain decisions. Such black-box models are difficult to comprehend not only for targeted users and decision-makers but also for AI developers. Besides, in sensitive areas like healthcare, explainability and accountability are not only desirable properties of AI but also legal requirements -- especially when AI may have significant impacts on human lives. Explainable artificial intelligence (XAI) is an emerging field that aims to mitigate the opaqueness of black-box models and make it possible to interpret how AI systems make their decisions with transparency. An interpretable ML model can explain how it makes predictions and which factors affect the model's outcomes. The majority of state-of-the-art interpretable ML methods have been developed in a domain-agnostic way and originate from computer vision, automated reasoning, or even statistics. Many of these methods cannot be directly applied to bioinformatics problems, without prior customization, extension, and domain adoption. In this paper, we discuss the importance of explainability with a focus on bioinformatics. We analyse and comprehensively overview of model-specific and model-agnostic interpretable ML methods and tools. Via several case studies covering bioimaging, cancer genomics, and biomedical text mining, we show how bioinformatics research could benefit from XAI methods and how they could help improve decision fairness.

Curriculum learning and self-paced learning are the training strategies that gradually feed the samples from easy to more complex. They have captivated increasing attention due to their excellent performance in robotic vision. Most recent works focus on designing curricula based on difficulty levels in input samples or smoothing the feature maps. However, smoothing labels to control the learning utility in a curriculum manner is still unexplored. In this work, we design a paced curriculum by label smoothing (P-CBLS) using paced learning with uniform label smoothing (ULS) for classification tasks and fuse uniform and spatially varying label smoothing (SVLS) for semantic segmentation tasks in a curriculum manner. In ULS and SVLS, a bigger smoothing factor value enforces a heavy smoothing penalty in the true label and limits learning less information. Therefore, we design the curriculum by label smoothing (CBLS). We set a bigger smoothing value at the beginning of training and gradually decreased it to zero to control the model learning utility from lower to higher. We also designed a confidence-aware pacing function and combined it with our CBLS to investigate the benefits of various curricula. The proposed techniques are validated on four robotic surgery datasets of multi-class, multi-label classification, captioning, and segmentation tasks. We also investigate the robustness of our method by corrupting validation data into different severity levels. Our extensive analysis shows that the proposed method improves prediction accuracy and robustness.

Task agnostic generative pretraining (GPT) has recently proved promising for zero- and few-shot learning, gradually diverting attention from the expensive supervised learning paradigm. Although the community is accumulating knowledge as to capabilities of English-language autoregressive models such as GPT-3 adopting this generative approach, scholarship about these models remains acutely Anglocentric. Consequently, the community currently has serious gaps in its understanding of this class of models, their potential, and their societal impacts in diverse settings, linguistic traditions, and cultures. To alleviate this issue for Arabic, a collection of diverse languages and language varieties with more than $400$ million population, we introduce JASMINE, a suite of powerful Arabic autoregressive Transformer language models ranging in size between 300 million-13 billion parameters. We pretrain our new models with large amounts of diverse data (400GB of text) from different Arabic varieties and domains. We evaluate JASMINE extensively in both intrinsic and extrinsic settings, using a comprehensive benchmark for zero- and few-shot learning across a wide range of NLP tasks. We also carefully develop and release a novel benchmark for both automated and human evaluation of Arabic autoregressive models focused at investigating potential social biases, harms, and toxicity in these models. We aim to responsibly release our models with interested researchers, along with code for experimenting with them